' 
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
5.3
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
8
Folate may enhance UTI treatment
Using Functional Annotations to Study Pairwise Interactions in Urinary Tract Infection Communities.
Study shows promising initial results
We devised a computational approach to examine how certain compounds, specifically folate, influence microbial communities involved in urinary tract infections (UTIs). By analyzing 66 genomes from various UTI-related bacteria, we looked closely at their metabolic interactions to predict if supplementary folate could enhance bacterial growth.
Our findings suggested that some bacterial species could indeed benefit from folate, particularly when supplied alongside other community members that produce complementary metabolites. To put our predictions to the test, we experimented with folate supplementation, which resulted in an impressive increase in the population density of UTI isolates.
This study indicates a promising link between folate and UTI treatment, revealing how beneficial interactions between different bacteria can be harnessed for improved health outcomes. While additional studies will be needed for further validation, our method offers a quick and effective way to explore and understand these microbial partnerships.
Our findings suggested that some bacterial species could indeed benefit from folate, particularly when supplied alongside other community members that produce complementary metabolites. To put our predictions to the test, we experimented with folate supplementation, which resulted in an impressive increase in the population density of UTI isolates.
This study indicates a promising link between folate and UTI treatment, revealing how beneficial interactions between different bacteria can be harnessed for improved health outcomes. While additional studies will be needed for further validation, our method offers a quick and effective way to explore and understand these microbial partnerships.
Read More
4
Folate's isolated effects unclear
Daily intake of 100 mg ascorbic acid as urinary tract infection prophylactic agent during pregnancy.
Relevance score indicates limited impact
We conducted a study to assess the impact of taking folate alongside other supplements in preventing urinary tract infections (UTIs) in pregnant women. The research involved a group of expectant mothers who were given a daily combination of ferrous sulfate, folic acid, and ascorbic acid, compared to another group that only received ferrous sulfate and folic acid. Both groups were monitored for three months, with monthly urine cultures to check for infections.
The findings revealed that while overall urinary infections occurred in about a quarter of the participants, the group receiving ascorbic acid showed a significantly lower infection rate. However, we didn't specifically isolate the effects of folate alone since it was administered with other treatments. This means that while folate plays a crucial role in pregnancy and health, its direct impact on UTIs in our study couldn't be conclusively determined.
Therefore, though we observed some benefits from adding ascorbic acid, we must be cautious about claiming folate's effectiveness in reducing urinary infections based solely on this study. Further research is necessary to clarify these relationships and assess folate's potential role in urinary health during pregnancy.
The findings revealed that while overall urinary infections occurred in about a quarter of the participants, the group receiving ascorbic acid showed a significantly lower infection rate. However, we didn't specifically isolate the effects of folate alone since it was administered with other treatments. This means that while folate plays a crucial role in pregnancy and health, its direct impact on UTIs in our study couldn't be conclusively determined.
Therefore, though we observed some benefits from adding ascorbic acid, we must be cautious about claiming folate's effectiveness in reducing urinary infections based solely on this study. Further research is necessary to clarify these relationships and assess folate's potential role in urinary health during pregnancy.
Read More
4
L-methionine raises homocysteine levels
Effect of L-methionine supplementation on plasma homocysteine and other free amino acids: a placebo-controlled double-blind cross-over study.
Limited folate impact on UTIs
We conducted a study to find out how the essential amino acid L-methionine impacts metabolism, especially homocysteine levels, in women with chronic urinary tract infections (UTIs) compared to healthy individuals. Our research involved a randomized, placebo-controlled, double-blind design with a crossover approach, including eight female patients with recurring UTIs and twelve healthy women as controls.
After a methionine-loading test, each participant received either a dose of L-methionine or a placebo three times daily for four weeks. We measured serum and urinary levels of several amino acids, including methionine, homocysteine, and others, along with vitamins like B12, B6, and folate status.
Despite our rigorous methods and proper vitamin levels among participants, we found that taking 1500 mg of L-methionine daily significantly increased plasma homocysteine concentrations by an average of 2 micromol/l, in both UTI patients and healthy subjects. We concluded that even optimal folate supplementation might not be enough to prevent such increases in homocysteine levels, and we did not find significant evidence that folate worked independently against UTIs in this context.
After a methionine-loading test, each participant received either a dose of L-methionine or a placebo three times daily for four weeks. We measured serum and urinary levels of several amino acids, including methionine, homocysteine, and others, along with vitamins like B12, B6, and folate status.
Despite our rigorous methods and proper vitamin levels among participants, we found that taking 1500 mg of L-methionine daily significantly increased plasma homocysteine concentrations by an average of 2 micromol/l, in both UTI patients and healthy subjects. We concluded that even optimal folate supplementation might not be enough to prevent such increases in homocysteine levels, and we did not find significant evidence that folate worked independently against UTIs in this context.
Read More
Most Useful Reviews
9.5
Resolved infections
My experience with folate before pregnancy led to dryness in my vagina and urinary tract infections. Thankfully, these issues cleared up, thanks to this product. The amount of folate lasts for three months, and it does not upset my stomach like some other products.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
5.3
- All Researches
8
Folate may enhance UTI treatment
Using Functional Annotations to Study Pairwise Interactions in Urinary Tract Infection Communities.
Study shows promising initial results
We devised a computational approach to examine how certain compounds, specifically folate, influence microbial communities involved in urinary tract infections (UTIs). By analyzing 66 genomes from various UTI-related bacteria, we looked closely at their metabolic interactions to predict if supplementary folate could enhance bacterial growth.
Our findings suggested that some bacterial species could indeed benefit from folate, particularly when supplied alongside other community members that produce complementary metabolites. To put our predictions to the test, we experimented with folate supplementation, which resulted in an impressive increase in the population density of UTI isolates.
This study indicates a promising link between folate and UTI treatment, revealing how beneficial interactions between different bacteria can be harnessed for improved health outcomes. While additional studies will be needed for further validation, our method offers a quick and effective way to explore and understand these microbial partnerships.
Our findings suggested that some bacterial species could indeed benefit from folate, particularly when supplied alongside other community members that produce complementary metabolites. To put our predictions to the test, we experimented with folate supplementation, which resulted in an impressive increase in the population density of UTI isolates.
This study indicates a promising link between folate and UTI treatment, revealing how beneficial interactions between different bacteria can be harnessed for improved health outcomes. While additional studies will be needed for further validation, our method offers a quick and effective way to explore and understand these microbial partnerships.
Read More
4
Folate's isolated effects unclear
Daily intake of 100 mg ascorbic acid as urinary tract infection prophylactic agent during pregnancy.
Relevance score indicates limited impact
We conducted a study to assess the impact of taking folate alongside other supplements in preventing urinary tract infections (UTIs) in pregnant women. The research involved a group of expectant mothers who were given a daily combination of ferrous sulfate, folic acid, and ascorbic acid, compared to another group that only received ferrous sulfate and folic acid. Both groups were monitored for three months, with monthly urine cultures to check for infections.
The findings revealed that while overall urinary infections occurred in about a quarter of the participants, the group receiving ascorbic acid showed a significantly lower infection rate. However, we didn't specifically isolate the effects of folate alone since it was administered with other treatments. This means that while folate plays a crucial role in pregnancy and health, its direct impact on UTIs in our study couldn't be conclusively determined.
Therefore, though we observed some benefits from adding ascorbic acid, we must be cautious about claiming folate's effectiveness in reducing urinary infections based solely on this study. Further research is necessary to clarify these relationships and assess folate's potential role in urinary health during pregnancy.
The findings revealed that while overall urinary infections occurred in about a quarter of the participants, the group receiving ascorbic acid showed a significantly lower infection rate. However, we didn't specifically isolate the effects of folate alone since it was administered with other treatments. This means that while folate plays a crucial role in pregnancy and health, its direct impact on UTIs in our study couldn't be conclusively determined.
Therefore, though we observed some benefits from adding ascorbic acid, we must be cautious about claiming folate's effectiveness in reducing urinary infections based solely on this study. Further research is necessary to clarify these relationships and assess folate's potential role in urinary health during pregnancy.
Read More
4
L-methionine raises homocysteine levels
Effect of L-methionine supplementation on plasma homocysteine and other free amino acids: a placebo-controlled double-blind cross-over study.
Limited folate impact on UTIs
We conducted a study to find out how the essential amino acid L-methionine impacts metabolism, especially homocysteine levels, in women with chronic urinary tract infections (UTIs) compared to healthy individuals. Our research involved a randomized, placebo-controlled, double-blind design with a crossover approach, including eight female patients with recurring UTIs and twelve healthy women as controls.
After a methionine-loading test, each participant received either a dose of L-methionine or a placebo three times daily for four weeks. We measured serum and urinary levels of several amino acids, including methionine, homocysteine, and others, along with vitamins like B12, B6, and folate status.
Despite our rigorous methods and proper vitamin levels among participants, we found that taking 1500 mg of L-methionine daily significantly increased plasma homocysteine concentrations by an average of 2 micromol/l, in both UTI patients and healthy subjects. We concluded that even optimal folate supplementation might not be enough to prevent such increases in homocysteine levels, and we did not find significant evidence that folate worked independently against UTIs in this context.
After a methionine-loading test, each participant received either a dose of L-methionine or a placebo three times daily for four weeks. We measured serum and urinary levels of several amino acids, including methionine, homocysteine, and others, along with vitamins like B12, B6, and folate status.
Despite our rigorous methods and proper vitamin levels among participants, we found that taking 1500 mg of L-methionine daily significantly increased plasma homocysteine concentrations by an average of 2 micromol/l, in both UTI patients and healthy subjects. We concluded that even optimal folate supplementation might not be enough to prevent such increases in homocysteine levels, and we did not find significant evidence that folate worked independently against UTIs in this context.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Resolved infections
My experience with folate before pregnancy led to dryness in my vagina and urinary tract infections. Thankfully, these issues cleared up, thanks to this product. The amount of folate lasts for three months, and it does not upset my stomach like some other products.
